Chemical Engineering Fundamentals in Biological Systems Multimedia Modules

The following multimedia-based educational materials, developed
under the NSF Combined Research Curriculum Development Program, NSF
Grant EEC-9420567, focus on applications of chemical engineering
concepts in biological systems. The modules provide interactive reviews
of chemical engineering fundamentals. Real world examples increase
students’ interest in the material and provide real world applications
of these fundamentals. Many of the modules also include simulations
that allow students to explore the role of process parameters.

 

BALANCES – Material balances in biological
systems

This module helps students in the introductory chemical engineering
course understand and practice the application of material balances to
biological systems of different dimensions using an algorithm for the
solution of material balance problems. In-depth interactions focus on
mass balance problems involving cell metabolism, an artificial kidney,
and a cheese factory.

DIFFUSION – Oxygen diffusion through the body

This module focuses on the convection and diffusion of oxygen
through the body . The introduction consists of a review of convection
and diffusion, and their effects on oxygen transport. The quantitative
analysis section presents the relevant equations of convection and
diffusion and presents the Krogh cylinder model, which illustrates how
convection and diffusion compete in oxygen transfer through veins. The
second edition (Summer 1998) will include two case studies.

 

ADSORPTION – Adsorption-based bio-separation

This module focuses on applications of adsorption. The Introduction
section explains the concept of adsorption , including an animation of
the adsorption process. The Modeling and Equations section displays a
mathematical model of adsorption. A simulator allows the user to select
values for adsorbent diameter, length of column, inlet flow rate,
maximum concentration of solute on adsorbent, and the adsorption
constant, and learn the relative effects on column performance. A case
study explores how protein A binds to the Fc portion of immunoglobulins
and is isolated from other proteins.

 

RECEPTORS – Kinetics of receptor-ligand
interactions

This module reinforces concepts of kinetics in the context of
receptor-ligand binding. The Introduction focuses on receptor-ligand
binding and corresponding analysis techniques. The Interaction/Kinetics
section focuses on the quantitative kinetics of simple receptor-ligand
binding. A simulator allows the user to explore the effect of ligand
concentration, reaction rate constants, total receptors and initial
complexes on receptor-ligand binding. An allergy case study explores
the role of signal transduction in allergic responses. A tissue
engineering case study focuses on the seeding of cells on an artificial
matrix.

 

BIOREMEDIATION – Kinetics and bioremediation

This module focuses on applications of kinetics to bioremediation
and bacteria profile modification. It begins with an introduction to
biological reacti ons, cells, types of reactors, and products. A
quantitative approach to characterize kinetics and reactors is reviewed
for both batch and continuous reactors. The Bacterial Profile
Modification section introduces the user to applications of BPM to oil
recovery. The user can use a simulation of the growth of cells in a
batch reactor to explore the effects of cell and sugar concentrations
and various kinetic parameters on cell growth. Requirements for
successful bioremediation and different bioremediation techniques such
as biostimulation and bioaugmentation are also explored. Available from
CACHE office August, 1997

 

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